Scientist - Upstream Process Development
Hays Specialist Recruitment Limited · London · posted 16 days ago
Occupation
Going rate for this occupation: £54,600 · UK median pay £55,518
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Your new company As an Upstream Process Scientist, you'll be joining a well-established global biopharmaceutical organisation in the Reading / Slough / London area developing innovative biologic therapies. You'll be part of a multidisciplinary process sciences team focused on advancing manufacturing processes for antibodies and proteins from early development through to technology transfer and manufacturing support. Your new role As an Associate Scientist / Research Scientist in the Upstream Process Development team, you will support the development, optimisation, and scale-up of mammalian cell culture processes for biologics manufacturing. This is initially a 12 month contract that is likely to extend and is fully lab-based. Key responsibilities include:
Designing and carrying out upstream process development studies using mammalian cell culture systems (eg CHO) Applying DoE and QbD approaches to process optimisation and characterisation Operating shake flasks, Ambr platforms, and laboratory-scale bioreactors to generate high-quality process data Supporting scale-up activities, process troubleshooting, technology transfer, and manufacturing support programmes for antibody and protein therapeutics Using automation and high-throughput technologies to improve process development efficiency Analysing experimental data and communicating findings to project teams and stakeholders Preparing technical reports, protocols, presentations, and scientific documentation Collaborating with cell line development, analytical sciences, downstream development, manufacturing, and external partners
What you'll need to succeed A successful candidate will combine practical upstream development experience with strong scientific and problem-solving skills.You should also have:
A BSc or MSc (or equivalent experience) in Biotechnology, Bioprocess Engineering, Cell Biology, Molecular Biology, Chemical Engineering, or a related discipline Hands-on experience in mammalian cell culture and biologics process development, preferably in an industry setting, eg biotech, CRO or pharmaceutical company Experience working with mammalian cell culture and therapeutic protein production, experience with CHO cells is an advantage Practical experience operating Ambr systems and/or laboratory-scale bioreactors Understanding of process characterisation, scale-up principles, and upstream process optimisation Experience applying DoE and statistical analysis approaches Strong troubleshooting and scientific problem-solving capability Experience using automation technologies, digital tools, or laboratory data management systems Excellent communication and technical writing skills
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